SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

Mol Aspects Med. 2013 Apr-Jun;34(2-3):236-51. doi: 10.1016/j.mam.2012.05.001.


This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cation Transport Proteins / chemistry
  • Homeostasis / genetics
  • Humans
  • Models, Molecular*
  • Multigene Family / genetics*
  • Organelles / metabolism*
  • Phylogeny
  • Protein Conformation*
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Hydrogen Exchangers / chemistry
  • Sodium-Hydrogen Exchangers / classification
  • Sodium-Hydrogen Exchangers / genetics*
  • Sodium-Hydrogen Exchangers / metabolism
  • Sodium-Hydrogen Exchangers / physiology*


  • Cation Transport Proteins
  • SLC9A1 protein, human
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Hydrogen Exchangers