The SLC12 family of electroneutral cation-coupled chloride cotransporters

Mol Aspects Med. 2013 Apr-Jun;34(2-3):288-98. doi: 10.1016/j.mam.2012.05.002.


The SLC12 family encodes electroneutral cation-coupled chloride cotransporters that are critical for several physiological processes including cell volume regulation, modulation of intraneuronal chloride concentration, transepithelial ion movement, and blood pressure regulation. Members of this family are the targets of the most commonly used diuretic drugs, have been shown to be the causative genes for inherited disease such as Gitelman, Bartter and Andermann syndromes, and potentially play a role in polygenic complex diseases like arterial hypertension, epilepsy, osteoporosis, and cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Pressure / genetics
  • Blood Pressure / physiology
  • Diuretics / pharmacology
  • Humans
  • K Cl- Cotransporters
  • Models, Biological
  • Models, Molecular*
  • Multigene Family / genetics*
  • Sodium-Potassium-Chloride Symporters / genetics*
  • Sodium-Potassium-Chloride Symporters / metabolism
  • Sodium-Potassium-Chloride Symporters / physiology*
  • Symporters / genetics*
  • Symporters / metabolism
  • Symporters / physiology*


  • Diuretics
  • Sodium-Potassium-Chloride Symporters
  • Symporters