Surface modification of implants in long bone

Biomatter. Jul-Sep 2012;2(3):149-57. doi: 10.4161/biom.21563.


Coatings of orthopedic implants are investigated to improve the osteoinductive and osteoconductive properties of the implant surfaces and thus to enhance periimplant bone formation. By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. The influence of these components on cells, the inflammation process, new bone formation and bone/implant contact is summarized.

Keywords: RGD peptide; bone healing; chondroitin sulfate; collagen type I; hyaluronic acid; hydroxyapatite; implants; titanium.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Substitutes*
  • Bone and Bones / pathology*
  • Cell Differentiation
  • Cell Proliferation
  • Chondroitin Sulfates / chemistry
  • Coated Materials, Biocompatible / chemistry*
  • Collagen / chemistry
  • Cytokines / metabolism
  • Durapatite / chemistry
  • Extracellular Matrix / metabolism
  • Femur / pathology
  • Humans
  • Implants, Experimental
  • Oligopeptides / chemistry
  • Osseointegration
  • Osteoblasts / cytology
  • Osteoclasts / cytology
  • Prostheses and Implants
  • Rats
  • Tibia / pathology
  • Titanium / chemistry


  • Bone Substitutes
  • Coated Materials, Biocompatible
  • Cytokines
  • Oligopeptides
  • arginyl-glycyl-aspartic acid
  • Chondroitin Sulfates
  • Collagen
  • Durapatite
  • Titanium