Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1990 Apr;30(4):375-84.

Indomethacin Treatment of Human Adult Respiratory Distress Syndrome

Affiliations
  • PMID: 2350875
Clinical Trial

Indomethacin Treatment of Human Adult Respiratory Distress Syndrome

S M Steinberg et al. Circ Shock. .

Abstract

The purpose of this investigation was to evaluate the magnitude and duration of changes in lung function and oxygen transport in patients with adult respiratory distress syndrome (ARDS) receiving indomethacin. Ten patients with ARDS were randomized to receive intravenously either a single 50 mg dose of indomethacin or placebo. Comparing 1 hr postinfusion levels to baseline observations in the indomethacin group, PaO2 increased to 125 +/- 13 torr from 93 +/- 8 torr, PaO2/FIO2 ratio increased to 223 +/- 24 from 160 +/- 5, and Qs/Qt dropped to 0.20 +/- 0.03 from 0.27 +/- 0.03 (all P less than 0.05). These alterations in oxygenation gradually returned to baseline levels over the ensuing 8 hr. No such changes were noted in the placebo group.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

LinkOut - more resources

Feedback