Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Cell Mol Life Sci. 2013 Nov;70(21):4009-21. doi: 10.1007/s00018-013-1307-3. Epub 2013 Mar 19.

Abstract

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites. However, recent work has identified a splice variant of Chk1, which may regulate Chk1 in both DDR and normal cell cycle via molecular interaction. Upon activation, Chk1 phosphorylates a variety of substrate proteins, resulting in the activation of DNA damage checkpoints, cell cycle arrest, DNA repair, and/or cell death. Chk1 and its related signaling may be an effective therapeutic target in diseases such as cancer.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Cycle Checkpoints*
  • Checkpoint Kinase 1
  • DNA Damage*
  • DNA Repair
  • Humans
  • Molecular Sequence Data
  • Neoplasms / metabolism*
  • Phosphorylation
  • Protein Binding
  • Protein Kinases / metabolism*
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Species Specificity

Substances

  • Protein Kinases
  • CHEK1 protein, human
  • Checkpoint Kinase 1