Uveitis is defined as inflammation of the vascular tunic of the eye, the uvea. Although inflammation can affect the entire uvea, clinical signs may present predominantly in either the anterior or the posterior chamber. Anterior uveitis lesions may affect the cornea, anterior chamber, iris, and lens, whereas posterior uveitis anomalies may be located in the vitreous and fundus. Uveal inflammation is often a sentinel finding indicative of underlying systemic pathology. Causes of feline uveitis are numerous, with infectious disease being the most common. Clinical signs are often nonspecific, and recurrence of disease is common, posing the challenges of accurate diagnosis and appropriate treatment.