Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats

Biomed Res Int. 2013;2013:162724. doi: 10.1155/2013/162724. Epub 2012 Dec 20.

Abstract

The Ginkgo biloba extract (GBE) has been reported to have a wide range of health benefits in traditional Chinese medicine. The aim of this study was to evaluate the antihyperglycemic effects of GBE on streptozotocin- (STZ-) induced diabetes in rats. Diabetes was induced in male Wistar rats by the administration of STZ (60 mg/kg b.w.) intraperitoneally. GBE (100, 200, and 300 mg/kg b.w.) was administered orally once a day for a period of 30 days. Body weight and blood glucose levels were determined in different experimental days. Serum lipid profile and antioxidant enzymes in hepatic and pancreatic tissue were measured at the end of the experimental period. Significant decreases in body weight and antioxidant ability and increases in blood glucose, lipid profile, and lipid peroxidation were observed in STZ-induced diabetic rats. The administration of GBE and glibenclamide daily for 30 days in STZ-induced diabetic rats reversed the above parameters significantly. GBE possesses antihyperglycemic, antioxidant, and antihyperlipidemia activities in STZ-induced chronic diabetic rats, which promisingly support the use of GBE as a food supplement or an adjunct treatment for diabetics.

MeSH terms

  • Administration, Oral
  • Animals
  • Antioxidants / metabolism
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Body Weight / drug effects
  • Diabetes Mellitus, Experimental / drug therapy*
  • Free Radicals
  • Ginkgo biloba / metabolism*
  • Hypoglycemic Agents / pharmacology*
  • Lipid Peroxidation
  • Male
  • Oxidative Stress
  • Phytotherapy / methods
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • Blood Glucose
  • Free Radicals
  • Hypoglycemic Agents
  • Plant Extracts