Abstract
The first total synthesis of stereochemically pure resolvin D3 and aspirin-triggered resolvin D3 is reported. These enzymatic metabolites of docosahexaenoic acid (DHA) have potent anti-inflammatory and pro-resolving actions. The convergent synthetic strategy is based on enantiomerically pure starting materials, and it is highly stereocontrolled.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Aspirin / pharmacology*
-
Fatty Acids, Unsaturated / chemical synthesis*
-
Fatty Acids, Unsaturated / chemistry
-
Fatty Acids, Unsaturated / pharmacology*
-
Inflammation Mediators / physiology
-
Lipid Metabolism
-
Molecular Structure
-
Stereoisomerism
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Fatty Acids, Unsaturated
-
Inflammation Mediators
-
resolvin D3
-
Aspirin