A map of Alzheimer's disease-signaling pathways: a hope for drug target discovery

Clin Pharmacol Ther. 2013 May;93(5):399-401. doi: 10.1038/clpt.2013.37. Epub 2013 Feb 20.


Alzheimer’s disease (AD) is a complex neurodegenerative condition, and its drug therapy is challenging. To inform AD drug discovery, we developed the “AlzPathway,” a prototype of a comprehensive map of AD-related signaling pathways, from information obtained through studies in the public domain. The AlzPathway provides an integrated platform for systems analyses of AD-signaling pathways and networks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / physiopathology*
  • Drug Design
  • Drug Discovery / methods*
  • Humans
  • Molecular Targeted Therapy*
  • Signal Transduction
  • Systems Biology