Corticostriatal connectivity and its role in disease

Nat Rev Neurosci. 2013 Apr;14(4):278-91. doi: 10.1038/nrn3469.


Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders - autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / cytology
  • Cerebral Cortex / physiology*
  • Corpus Striatum / cytology
  • Corpus Striatum / physiology*
  • Developmental Disabilities / pathology*
  • Humans
  • Mental Disorders / pathology*
  • Movement Disorders / pathology*
  • Neural Pathways / physiology*
  • Neurons / physiology