HLA-B*5701 genetic screening among HIV-1 infected patients in Hong Kong: is this a practical approach in Han-Chinese?

Int J STD AIDS. 2013 Jan;24(1):50-2. doi: 10.1258/ijsa.2012.012102. Epub 2013 May 6.

Abstract

Abacavir hypersensitivity is associated with the presence of human leukocyte antigen (HLA)-allele B*5701. However, the cost and workload of routine HLA-B*5701 pretreatment screening is relatively heavy. This study aimed to determine the prevalence of the HLA-B*5701 allele in the HIV-positive population under care in Hong Kong. Blood samples from 1264 HIV-1 infected patients in Hong Kong were collected between 2007 and 2011 for this study. HLA-B*5701 screening of the study group was determined by in-house polymerase chain reaction (PCR) followed by confirmation using the AlleleSEQR(®) HLA-B PCR/Sequencing Kit (Celera Corporation for Abbott, San Francisco, USA). HLA-B*5701 carriers were identified among 3% of Caucasians, 1% of non-Chinese Asians and 0.5% of Han-Chinese in Hong Kong. Our findings revealed that HLA-B*5701 pretreatment screening might not be necessary for the local Han-Chinese population due to its low prevalence.

Keywords: HLA-B*5701; Han-Chinese; Hong Kong; abacavir hypersensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Asian Continental Ancestry Group / genetics*
  • Dideoxynucleosides / therapeutic use*
  • Drug Hypersensitivity / genetics*
  • Female
  • Genetic Markers
  • Genetic Testing / methods*
  • Genotype
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • HIV-1 / genetics
  • HLA-B Antigens / blood
  • HLA-B Antigens / genetics*
  • Hong Kong
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Reverse Transcriptase Inhibitors / adverse effects*
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Young Adult

Substances

  • Dideoxynucleosides
  • Genetic Markers
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • Reverse Transcriptase Inhibitors
  • abacavir