Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice

Nat Prod Commun. 2013 Feb;8(2):153-4.


The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation-promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Diterpenes / pharmacology*
  • Female
  • Hydroxylamines / pharmacology*
  • Mice
  • Mice, Hairless
  • Skin Neoplasms / prevention & control*
  • Tetradecanoylphorbol Acetate


  • (+-)-E-4-methyl-2-((E)-hydroxylamino)-5-nitro-6-methoxy-3-hexanamide
  • Anticarcinogenic Agents
  • Diterpenes
  • Hydroxylamines
  • sarcophine-diol
  • Tetradecanoylphorbol Acetate