Gene loops and HDACs to promote transcription directionality

Nucleus. Mar-Apr 2013;4(2):92-4. doi: 10.4161/nucl.24236. Epub 2013 Mar 1.


Gene loops have been described in different organisms from yeast to human and form through interaction between components of the transcription pre-initiation complex and Ssu72, a member of the 3' end cleavage and polyadenylation complex. A recent study by Tan-Wong et al. reports a new role for gene loops in promoting ORF transcription directionality from otherwise bidirectional promoters.

Keywords: antisense RNA; bidirectional promoters; gene loop; histone deacetylase; non-coding RNA.

MeSH terms

  • Acetylation
  • Histone Deacetylases / genetics*
  • Histone Deacetylases / metabolism
  • Histones / genetics
  • Humans
  • Promoter Regions, Genetic*
  • RNA / genetics*
  • Transcription, Genetic*
  • Yeasts / genetics


  • Histones
  • RNA
  • Histone Deacetylases