In early 2012, three clusters of human Salmonella infections were identified through PulseNet, a national network of public health and food regulatory agency laboratories coordinated by CDC that subtypes disease-causing organisms. Initial investigations indicated many of the ill persons in these three clusters had contact with live poultry (e.g., chicks and ducklings) from a single mail-order hatchery; therefore, the three investigations were merged. During March 1-September 24, 2012, a total of 195 persons infected with the outbreak strains of Salmonella serotypes Infantis, Newport, and Lille were reported from 27 states.