PHISTO: pathogen-host interaction search tool

Bioinformatics. 2013 May 15;29(10):1357-8. doi: 10.1093/bioinformatics/btt137. Epub 2013 Mar 20.

Abstract

Summary: Knowledge of pathogen-host protein interactions is required to better understand infection mechanisms. The pathogen-host interaction search tool (PHISTO) is a web-accessible platform that provides relevant information about pathogen-host interactions (PHIs). It enables access to the most up-to-date PHI data for all pathogen types for which experimentally verified protein interactions with human are available. The platform also offers integrated tools for visualization of PHI networks, graph-theoretical analysis of targeted human proteins, BLAST search and text mining for detecting missing experimental methods. PHISTO will facilitate PHI studies that provide potential therapeutic targets for infectious diseases.

Availability: http://www.phisto.org.

Contact: saliha.durmus@boun.edu.tr

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Communicable Diseases
  • Data Mining*
  • Databases, Protein
  • Host-Pathogen Interactions*
  • Humans
  • Internet
  • Protein Interaction Domains and Motifs
  • Search Engine*