T Cell-Mediated Host Immune Defenses in the Lung

Annu Rev Immunol. 2013;31:605-33. doi: 10.1146/annurev-immunol-032712-100019.


Evidence has increasingly shown that the lungs are a major site of immune regulation. A robust and highly regulated immune response in the lung protects the host from pathogen infection, whereas an inefficient or deleterious response can lead to various pulmonary diseases. Many cell types, such as epithelial cells, dendritic cells, macrophages, neutrophils, eosinophils, and B and T lymphocytes, contribute to lung immunity. This review focuses on the recent advances in understanding how T lymphocytes mediate pulmonary host defenses against bacterial, viral, and fungal pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / pathology*
  • Host-Pathogen Interactions / immunology
  • Humans
  • Lung / immunology*
  • Lung / microbiology
  • Lung / pathology*
  • Lymph Nodes / immunology
  • Lymph Nodes / microbiology
  • Lymph Nodes / pathology
  • Mycobacterium tuberculosis / immunology
  • Tuberculosis, Pulmonary / immunology*
  • Tuberculosis, Pulmonary / microbiology
  • Tuberculosis, Pulmonary / pathology