Abstract
In the present study, circulating proportions of CD8(+) T (Tc) cell subsets, including IL-17 (Tc17) and IL-10 (Tc10) producing cells, were assessed in relapsing-remitting MS (RRMS) patients and a possible effect of beta interferon (IFN-β), glatiramer acetate (GA), and vitamin D (VitD) on these cell subsets was investigated. We show that both Tc17 and Tc10 cell fractions are elevated in the circulation of RRMS patients in remission compared to healthy subjects and that these Tc subsets remain unaffected by current immune modulating regimens.
Copyright © 2013 Elsevier B.V. All rights reserved.
MeSH terms
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Adult
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CD8-Positive T-Lymphocytes / immunology*
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Female
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Flow Cytometry
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Glatiramer Acetate
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Humans
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Immunosuppressive Agents / therapeutic use
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Interferon-beta / therapeutic use
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Interleukin-10 / immunology
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Interleukin-17 / immunology
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Male
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / drug therapy
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Peptides / therapeutic use
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Radioimmunoassay
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Recurrence
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Remission Induction
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T-Lymphocyte Subsets / immunology*
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Vitamin D / blood
Substances
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Immunosuppressive Agents
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Interleukin-17
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Peptides
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Interleukin-10
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Vitamin D
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Glatiramer Acetate
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Interferon-beta