Tumor dissemination: an EMT affair

Cancer Cell. 2013 Mar 18;23(3):272-3. doi: 10.1016/j.ccr.2013.03.004.


A recent paper reports that circulating tumor cells (CTCs) from metastatic breast cancer patients exhibit heterogeneous epithelial and mesenchymal phenotypes and that CTCs display higher frequencies of partial or full-blown mesenchymal phenotype than carcinoma cells within primary tumors. Mesenchymal-like CTCs are also elevated in patients who are refractory to therapy.

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