The treatment of heart failure in the 21st century: is the glass half empty or half full?

Methodist Debakey Cardiovasc J. 2013 Jan-Mar;9(1):3-5. doi: 10.14797/mdcj-9-1-3.


The field of heart failure has seen striking advances during the past 50 years, yet the overall economic and social burden imposed by heart failure continues to rise. While neurohormonal models provide many insights in terms of explaining disease progression and informing drug development, mounting clinical evidence suggests that this model provides only a partial explanation of the disease. This paper evaluates the emerging models of heart failure and their potential to reverse the disturbing trends in heart failure morbidity and mortality.

Keywords: Winters Center for Heart Failure Research; acute decompensated HF; heart failure.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiology / trends*
  • Diffusion of Innovation
  • Forecasting
  • Heart Failure / metabolism
  • Heart Failure / mortality
  • Heart Failure / physiopathology
  • Heart Failure / therapy*
  • History, 21st Century
  • Humans
  • Precision Medicine / trends*
  • Prognosis
  • Translational Research, Biomedical / trends*

Grant support

Funding/Support: Dr. Bozkurt receives research funding from the National Institutes of Health and Forest Pharmaceutical. Dr. Mann receives research funding from the National Institutes of Health.