An alternative to the surgical repair of secundum type atrial septal defects (ASD) and of patent ductus arteriosus (PDA) is transcatheter closure. However, there is limited information about the efficacy of using percutaneous devices to close multiple ASDs. An 8-year-old female patient was admitted to our hospital with a cardiac murmur. A large secundum multi-fenestrated ASD (17 mm, 4.5 mm, 3 mm) and PDA (3 mm) were diagnosed upon echocardiographic examination. During cardiac catheterization, the PDA was closed with an Amplatzer Duct Occluder (6x4 mm) followed by the closure of the ASD with an Amplatzer septal occluder (22 mm) with no residual shunting. The percutaneous closure of multi-fenestrated ASD with PDA in pediatric patients may be considered as a first-choice treatment with minimal complications.