Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen

J Exp Med. 1990 Jun 1;171(6):2147-52. doi: 10.1084/jem.171.6.2147.


cDNA clones encoding CD31 have been isolated by transient expression. The sequence of CD31 expressed on human umbilical vein endothelial cells (HUVEC) is identical to that expressed on the monocyte-like cell line HL60. In HUVEC. CD31 is concentrated in regions of cell-cell contacts. CD31 is a member of the Ig superfamily and is most closely related to the carcinoembryonic antigen CEA, consisting of four contiguous C2 domains. The localization of CD31 to regions of cell-cell contacts, and the sequence similarity to CEA, a known intercellular adhesion molecule (ICAM), strongly suggest that CD31 may function as an ICAM, possibly mediating endothelial cell-cell contacts and also promoting interactions between leukocytes and endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal / genetics
  • Antibodies, Monoclonal / immunology
  • Antigens, Differentiation, Myelomonocytic / genetics*
  • Base Sequence
  • Carcinoembryonic Antigen / genetics*
  • Cell Adhesion Molecules / genetics*
  • Cells, Cultured
  • Cloning, Molecular*
  • DNA*
  • Endothelium, Vascular / metabolism
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Sequence Homology, Nucleic Acid


  • Antibodies, Monoclonal
  • Antigens, Differentiation, Myelomonocytic
  • Carcinoembryonic Antigen
  • Cell Adhesion Molecules
  • Platelet Endothelial Cell Adhesion Molecule-1
  • DNA

Associated data

  • GENBANK/M28526