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Review
. 2013 Jun;11(2):126-9.
doi: 10.1007/s11914-013-0145-4.

Notch signaling and bone remodeling

Jenna Regan  1 , Fanxin Long
Affiliations
Review

Notch signaling and bone remodeling

Jenna Regan et al. Curr Osteoporos Rep. 2013 Jun.

Abstract

Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.

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Conflict of interest statement

Disclosure

J Regan declares no conflicts of interest and F Long declares no conflicts of interest.

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References

    1. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009;137:216–33. - PMC - PubMed
    1. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell. 2009;16:633–47. - PubMed
    1. Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development. 2011;138:3593–612. - PubMed
    1. Canalis E. Notch signaling in osteoblasts. Sci Signal. 2008;1:pe17. - PubMed
    1. Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem. 2006;281:6203–10. - PubMed

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