Prohibitin ligands in cell death and survival: mode of action and therapeutic potential

Chem Biol. 2013 Mar 21;20(3):316-31. doi: 10.1016/j.chembiol.2013.02.006.

Abstract

Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical and clinical studies indicate that these PHB ligands may be useful in oncology, cardiology, and neurology, as well as against obesity. This review covers the physiological role of PHBs in health and diseases and current developments concerning PHB ligands.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Survival / drug effects
  • Disease
  • Drug Discovery
  • Humans
  • Ligands
  • Prohibitins
  • Repressor Proteins / metabolism*

Substances

  • Ligands
  • PHB protein, human
  • Prohibitins
  • Repressor Proteins