Phosphorylation and dephosphorylation of the RIG-I-like receptors: a safety latch on a fateful pathway

Immunity. 2013 Mar 21;38(3):402-3. doi: 10.1016/j.immuni.2013.02.014.


Activation of antiviral responses by RNA sensors RIG-I and MDA5 must be stringently controlled. In this issue of Immunity, Wies et al. (2013) show that a requirement for activation-induced dephosphorylation of these proteins reinforces this restriction.

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