Unilateral humoral rejection after reoperative single-lung transplant

Ann Thorac Surg. 2013 Apr;95(4):e79-81. doi: 10.1016/j.athoracsur.2012.09.089.


The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibody Formation
  • Bronchiolitis Obliterans / diagnosis
  • Bronchiolitis Obliterans / etiology*
  • Bronchiolitis Obliterans / immunology
  • Female
  • Graft Rejection / complications
  • Graft Rejection / diagnosis
  • Graft Rejection / immunology*
  • HLA Antigens / immunology*
  • Humans
  • Immunity, Humoral*
  • Lung Transplantation / methods*
  • Pulmonary Fibrosis / surgery
  • Reoperation
  • Risk Factors
  • Transplantation, Homologous


  • HLA Antigens