Diabetes in cystic fibrosis

Paediatr Respir Rev. 2013 May:14 Suppl 1:16-8. doi: 10.1016/j.prrv.2013.02.002. Epub 2013 Mar 20.


Cystic fibrosis related diabetes (CFRD) is a common complication of cystic fibrosis, caused by a fall in insulin secretion with age in individuals with pancreatic insufficiency. CFRD is associated with worse clinical status and increased mortality. Treatment of CFRD with insulin results in sustained improvements in lung function and nutrition. While clinical experience with insulin treatment in CF has increased, the selection of who to treat and glycaemic targets remain unclear.

MeSH terms

  • Blood Glucose / analysis*
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / drug therapy
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / etiology*
  • Glucose Intolerance
  • Glucose Tolerance Test
  • Humans
  • Insulin / therapeutic use*


  • Blood Glucose
  • Insulin