Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

doi:10.1016/j.bone.2013.03.008

. 2013 Aug;55(2):458-60.

doi: 10.1016/j.bone.2013.03.008. Epub 2013 Mar 22.

Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

Xi Huang, Youjia Xu, Nicola C Partridge

PMID: 23523718
PMCID: PMC4038444
DOI: 10.1016/j.bone.2013.03.008

Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

Xi Huang et al. Bone. 2013 Aug.

. 2013 Aug;55(2):458-60.

doi: 10.1016/j.bone.2013.03.008. Epub 2013 Mar 22.

Authors

Xi Huang, Youjia Xu, Nicola C Partridge

PMID: 23523718
PMCID: PMC4038444
DOI: 10.1016/j.bone.2013.03.008

No abstract available

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Figures

**Figure 1**
Changes of iron and sex hormones over the lifespan of a woman (A) and a man (B).

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References

1. Nielson CM, Klein RF, Orwoll ES. Sex and the single nucleotide polymorphism: Exploring the genetic causes of skeletal sex differences. J Bone Miner Res. 2012;27:2047–2050. - PMC - PubMed
1. Liu CT, Estrada K, Yerges-Armstrong LM, Amin N, Evangelou E, Li G, Minster RL, Carless MA, Kammerer CM, Oei L, Zhou Y, Alonso N, Dailiana Z, Eriksson J, Garcia-Giralt N, Giroux S, Husted LB, Khusainova RI, Koromila T, Kung AW, Lewis JR, Masi L, Mencej-Bedrac S, Nogues X, Patel MS, Prezelj J, Richards JB, Sham PC, Spector T, Vandenput L, Xiao SM, Zheng HF, Zhu K, Balcells S, Brandi ML, Frost M, Goltzman D, Gonzalez-Macias J, Karlsson M, Khusnutdinova EK, Kollia P, Langdahl BL, Ljunggren O, Lorentzon M, Marc J, Mellstrom D, Ohlsson C, Olmos JM, Ralston SH, Riancho JA, Rousseau F, Urreizti R, Van Hul W, Zarrabeitia MT, Castano-Betancourt M, Demissie S, Grundberg E, Herrera L, Kwan T, Medina-Gomez C, Pastinen T, Sigurdsson G, Thorleifsson G, Vanmeurs JB, Blangero J, Hofman A, Liu Y, Mitchell BD, O'Connell JR, Oostra BA, Rotter JI, Stefansson K, Streeten EA, Styrkarsdottir U, Thorsteinsdottir U, Tylavsky FA, Uitterlinden A, Cauley JA, Harris TB, Ioannidis JP, Psaty BM, Robbins JA, Zillikens MC, Vanduijn CM, Prince RL, Karasik D, Rivadeneira F, Kiel DP, Cupples LA, Hsu YH. Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res. 2012;27:2051–2064. - PMC - PubMed
1. Jian J, Pelle E, Huang X. Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal. 2009;11:2939–2943. - PMC - PubMed
1. Guggenbuhl P, Fergelot P, Doyard M, Libouban H, Roth MP, Gallois Y, Chales G, Loreal O, Chappard D. Bone status in a mouse model of genetic hemochromatosis. Osteoporos Int. 2011;22:2313–2319. - PubMed
1. Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med. 2009;15:259–266. - PubMed

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[1] Nielson CM, Klein RF, Orwoll ES. Sex and the single nucleotide polymorphism: Exploring the genetic causes of skeletal sex differences. J Bone Miner Res. 2012;27:2047–2050. - PMC - PubMed

[2] Nielson CM, Klein RF, Orwoll ES. Sex and the single nucleotide polymorphism: Exploring the genetic causes of skeletal sex differences. J Bone Miner Res. 2012;27:2047–2050. - PMC - PubMed

[3] Liu CT, Estrada K, Yerges-Armstrong LM, Amin N, Evangelou E, Li G, Minster RL, Carless MA, Kammerer CM, Oei L, Zhou Y, Alonso N, Dailiana Z, Eriksson J, Garcia-Giralt N, Giroux S, Husted LB, Khusainova RI, Koromila T, Kung AW, Lewis JR, Masi L, Mencej-Bedrac S, Nogues X, Patel MS, Prezelj J, Richards JB, Sham PC, Spector T, Vandenput L, Xiao SM, Zheng HF, Zhu K, Balcells S, Brandi ML, Frost M, Goltzman D, Gonzalez-Macias J, Karlsson M, Khusnutdinova EK, Kollia P, Langdahl BL, Ljunggren O, Lorentzon M, Marc J, Mellstrom D, Ohlsson C, Olmos JM, Ralston SH, Riancho JA, Rousseau F, Urreizti R, Van Hul W, Zarrabeitia MT, Castano-Betancourt M, Demissie S, Grundberg E, Herrera L, Kwan T, Medina-Gomez C, Pastinen T, Sigurdsson G, Thorleifsson G, Vanmeurs JB, Blangero J, Hofman A, Liu Y, Mitchell BD, O'Connell JR, Oostra BA, Rotter JI, Stefansson K, Streeten EA, Styrkarsdottir U, Thorsteinsdottir U, Tylavsky FA, Uitterlinden A, Cauley JA, Harris TB, Ioannidis JP, Psaty BM, Robbins JA, Zillikens MC, Vanduijn CM, Prince RL, Karasik D, Rivadeneira F, Kiel DP, Cupples LA, Hsu YH. Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res. 2012;27:2051–2064. - PMC - PubMed

[4] Liu CT, Estrada K, Yerges-Armstrong LM, Amin N, Evangelou E, Li G, Minster RL, Carless MA, Kammerer CM, Oei L, Zhou Y, Alonso N, Dailiana Z, Eriksson J, Garcia-Giralt N, Giroux S, Husted LB, Khusainova RI, Koromila T, Kung AW, Lewis JR, Masi L, Mencej-Bedrac S, Nogues X, Patel MS, Prezelj J, Richards JB, Sham PC, Spector T, Vandenput L, Xiao SM, Zheng HF, Zhu K, Balcells S, Brandi ML, Frost M, Goltzman D, Gonzalez-Macias J, Karlsson M, Khusnutdinova EK, Kollia P, Langdahl BL, Ljunggren O, Lorentzon M, Marc J, Mellstrom D, Ohlsson C, Olmos JM, Ralston SH, Riancho JA, Rousseau F, Urreizti R, Van Hul W, Zarrabeitia MT, Castano-Betancourt M, Demissie S, Grundberg E, Herrera L, Kwan T, Medina-Gomez C, Pastinen T, Sigurdsson G, Thorleifsson G, Vanmeurs JB, Blangero J, Hofman A, Liu Y, Mitchell BD, O'Connell JR, Oostra BA, Rotter JI, Stefansson K, Streeten EA, Styrkarsdottir U, Thorsteinsdottir U, Tylavsky FA, Uitterlinden A, Cauley JA, Harris TB, Ioannidis JP, Psaty BM, Robbins JA, Zillikens MC, Vanduijn CM, Prince RL, Karasik D, Rivadeneira F, Kiel DP, Cupples LA, Hsu YH. Assessment of gene-by-sex interaction effect on bone mineral density. J Bone Miner Res. 2012;27:2051–2064. - PMC - PubMed

[5] Jian J, Pelle E, Huang X. Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal. 2009;11:2939–2943. - PMC - PubMed

[6] Jian J, Pelle E, Huang X. Iron and menopause: does increased iron affect the health of postmenopausal women? Antioxid Redox Signal. 2009;11:2939–2943. - PMC - PubMed

[7] Guggenbuhl P, Fergelot P, Doyard M, Libouban H, Roth MP, Gallois Y, Chales G, Loreal O, Chappard D. Bone status in a mouse model of genetic hemochromatosis. Osteoporos Int. 2011;22:2313–2319. - PubMed

[8] Guggenbuhl P, Fergelot P, Doyard M, Libouban H, Roth MP, Gallois Y, Chales G, Loreal O, Chappard D. Bone status in a mouse model of genetic hemochromatosis. Osteoporos Int. 2011;22:2313–2319. - PubMed

[9] Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med. 2009;15:259–266. - PubMed

[10] Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med. 2009;15:259–266. - PubMed

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Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

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