The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family

FEBS Lett. 2013 May 2;587(9):1399-404. doi: 10.1016/j.febslet.2013.03.017. Epub 2013 Mar 21.


Trypanosome protozoan parasites are the causative agents of devastating diseases. Trypanosome telomeres grow in an uncontrolled manner and the variant surface glycoprotein (VSG) genes are located in subtelomeric domains. The gene encoding telomerase reverse transcriptase (TERT) was identified and in this study, we describe the Trypanosoma brucei telomerase RNA (TER). TER RNA is bound by the core proteins of the C/D small nucleolar RNA (snoRNA) family and associates with the methyltransferase-associated protein (MTAP), whose homologue binds to mammalian TER. Silencing of TbTER resulted in telomere shortening. This is the first report of a TER that binds the C/D snoRNA core proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Molecular Sequence Data
  • Protein Binding
  • RNA / genetics*
  • RNA / metabolism*
  • RNA, Small Nucleolar / genetics*
  • RNA, Small Nucleolar / metabolism*
  • Ribonucleoproteins, Small Nucleolar / metabolism*
  • Sequence Homology, Nucleic Acid*
  • Telomerase / genetics*
  • Telomerase / metabolism*
  • Trypanosoma brucei brucei / enzymology*
  • Trypanosoma brucei brucei / genetics


  • RNA, Small Nucleolar
  • Ribonucleoproteins, Small Nucleolar
  • telomerase RNA
  • RNA
  • Telomerase