CD56 marks human dendritic cell subsets with cytotoxic potential

doi:10.4161/onci.23037

. 2013 Feb 1;2(2):e23037.

doi: 10.4161/onci.23037.

CD56 marks human dendritic cell subsets with cytotoxic potential

Dessie Roothans¹, Evelien Smits, Eva Lion, Jurjen Tel, Sébastien Anguille

Affiliations

PMID: 23524451
PMCID: PMC3601173
DOI: 10.4161/onci.23037

Free PMC article

CD56 marks human dendritic cell subsets with cytotoxic potential

Dessie Roothans et al. Oncoimmunology. 2013.

Free PMC article

. 2013 Feb 1;2(2):e23037.

doi: 10.4161/onci.23037.

Authors

Dessie Roothans¹, Evelien Smits, Eva Lion, Jurjen Tel, Sébastien Anguille

Affiliation

¹ Vaccine and Infectious Disease Institute (VAXINFECTIO); Laboratory of Experimental Hematology; University of Antwerp; Antwerp, Belgium.

PMID: 23524451
PMCID: PMC3601173
DOI: 10.4161/onci.23037

Abstract

Human plasmacytoid and myeloid dendritic cells (DCs), when appropriately stimulated, can express the archetypal natural killer (NK)-cell surface marker CD56. In addition to classical DC functions, CD56⁺ DCs are endowed with an unconventional cytotoxic capacity.

Keywords: CD56; cytotoxicity; dendritic cells; human; myeloid DCs; plasmacytoid DCs.

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Figures

None — **Figure 1.** The killing road: postulated mechanism of action of killer dendritic cells. The killer dendritic cell (DC) recognizes **(1)** and kills **(2)** tumor cells. Tumor cell-derived fragments are then captured by the killer DC **(3)**, internally processed **(4)** and subsequently presented on MHC molecules to CD4⁺ and CD8⁺ T cells **(5)**. Tumor antigen-specific CD8+ CTLs then lyse the remainder bulk of tumor cells **(6)**.

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References

1. Tel J, Smits EL, Anguille S, Joshi RN, Figdor CG, de Vries IJ. Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood. 2012;120:3936–44. doi: 10.1182/blood-2012-06-435941. - DOI - PubMed
1. Anguille S, Lion E, Tel J, de Vries IJM, Couderé K, Fromm PD, et al. Interleukin-15-induced CD56+ myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential. PLoS ONE. 2012;7(12):e51851. doi: 10.1371/journal.pone.0051851. - DOI - PMC - PubMed
1. Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med. 1996;183:1789–96. doi: 10.1084/jem.183.4.1789. - DOI - PMC - PubMed
1. Larmonier N, Fraszczak J, Lakomy D, Bonnotte B, Katsanis E. Killer dendritic cells and their potential for cancer immunotherapy. Cancer Immunol Immunother. 2010;59:1–11. doi: 10.1007/s00262-009-0736-1. - DOI - PubMed
1. Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage S. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation. Blood. 2012;119:4349–57. doi: 10.1182/blood-2011-11-395954. - DOI - PubMed

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[1] Tel J, Smits EL, Anguille S, Joshi RN, Figdor CG, de Vries IJ. Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood. 2012;120:3936–44. doi: 10.1182/blood-2012-06-435941. - DOI - PubMed

[2] Tel J, Smits EL, Anguille S, Joshi RN, Figdor CG, de Vries IJ. Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood. 2012;120:3936–44. doi: 10.1182/blood-2012-06-435941. - DOI - PubMed

[3] Anguille S, Lion E, Tel J, de Vries IJM, Couderé K, Fromm PD, et al. Interleukin-15-induced CD56+ myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential. PLoS ONE. 2012;7(12):e51851. doi: 10.1371/journal.pone.0051851. - DOI - PMC - PubMed

[4] Anguille S, Lion E, Tel J, de Vries IJM, Couderé K, Fromm PD, et al. Interleukin-15-induced CD56+ myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential. PLoS ONE. 2012;7(12):e51851. doi: 10.1371/journal.pone.0051851. - DOI - PMC - PubMed

[5] Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med. 1996;183:1789–96. doi: 10.1084/jem.183.4.1789. - DOI - PMC - PubMed

[6] Süss G, Shortman K. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med. 1996;183:1789–96. doi: 10.1084/jem.183.4.1789. - DOI - PMC - PubMed

[7] Larmonier N, Fraszczak J, Lakomy D, Bonnotte B, Katsanis E. Killer dendritic cells and their potential for cancer immunotherapy. Cancer Immunol Immunother. 2010;59:1–11. doi: 10.1007/s00262-009-0736-1. - DOI - PubMed

[8] Larmonier N, Fraszczak J, Lakomy D, Bonnotte B, Katsanis E. Killer dendritic cells and their potential for cancer immunotherapy. Cancer Immunol Immunother. 2010;59:1–11. doi: 10.1007/s00262-009-0736-1. - DOI - PubMed

[9] Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage S. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation. Blood. 2012;119:4349–57. doi: 10.1182/blood-2011-11-395954. - DOI - PubMed

[10] Guimont-Desrochers F, Boucher G, Dong Z, Dupuis M, Veillette A, Lesage S. Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation. Blood. 2012;119:4349–57. doi: 10.1182/blood-2011-11-395954. - DOI - PubMed

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CD56 marks human dendritic cell subsets with cytotoxic potential

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CD56 marks human dendritic cell subsets with cytotoxic potential

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