ImmTACs: Novel bi-specific agents for targeted cancer therapy

Oncoimmunology. 2013 Feb 1;2(2):e22891. doi: 10.4161/onci.22891.


Our expanding knowledge of the immune system is guiding a new era of targeted anticancer therapies. Here, we describe our recent work on a novel class of anticancer agents termed ImmTACs. These molecules combine the power of picomolar-affinity TCR-based antigen recognition with the immune-activating potential of an anti-CD3 antibody fragment, to potently redirect T-cell killing to tumor cells.

Keywords: CD3; ImmTAC; T cell receptor; immunotherapy; thymic selection.