Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression

Oncoimmunology. 2013 Feb 1;2(2):e22946. doi: 10.4161/onci.22946.


Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.

Keywords: Cancer; NETs; metastasis; neutrophils; thrombosis; tumor progression.

Publication types

  • Research Support, N.I.H., Extramural