Altered regional homogeneity in pediatric bipolar disorder during manic state: a resting-state fMRI study

PLoS One. 2013;8(3):e57978. doi: 10.1371/journal.pone.0057978. Epub 2013 Mar 6.


Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Previous fMRI studies investigating PBD were mainly task-related. However, little is known about the abnormalities in PBD, especially during resting state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder.

Methods: Regional homogeneity (ReHo) was examined with resting-state fMRI (RS-fMRI) on 15 patients with PBD in manic state, with 15 age-and sex-matched healthy youth subjects as controls.

Results: Compared with the healthy controls, the patients with PBD showed altered ReHo in the cortical and subcortical structures. The ReHo measurement of the PBD group was negatively correlated with the score of Young Mania Rating Scale (YMRS) in the superior frontal gyrus. Positive correlations between the ReHo measurement and the score of YMRS were found in the hippocampus and the anterior cingulate cortex in the PBD group.

Conclusions: Altered regional brain activity is present in patients with PBD during manic state. This study presents new evidence for abnormal ventral-affective and dorsal-cognitive circuits in PBD during resting state and may add fresh insights into the pathophysiological mechanisms underlying PBD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bipolar Disorder / pathology*
  • Bipolar Disorder / physiopathology*
  • Brain / pathology*
  • Brain / physiopathology*
  • Case-Control Studies
  • Caudate Nucleus / pathology
  • Caudate Nucleus / physiopathology
  • Child
  • Female
  • Frontal Lobe / pathology
  • Frontal Lobe / physiopathology
  • Hippocampus / pathology
  • Hippocampus / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology
  • Parietal Lobe / pathology
  • Parietal Lobe / physiopathology

Grant support

Natural Science Foundation of China: No. 81171291, 81201077. Key Program for Guangming Lu (Grant No BWS11J063, and No 10z026). Humanity and Social Science Youth foundation of Ministry of Education: No. 11YJC190039. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.