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, 8 (3), e58882

Virological Predictors of Response to Retreatment in Hepatitis C Genotype 2 Infected Patients

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Virological Predictors of Response to Retreatment in Hepatitis C Genotype 2 Infected Patients

Chung-Feng Huang et al. PLoS One.

Abstract

Background/aims: The impact of virological factors and interleukin-28B (IL-28B) genetic variants on retreatment of hepatitis C virus genotype 2 (HCV-2) treatment-experienced patients remains unknown.

Methods: On-treatment virological responses and IL-28B rs8099917 genotype were determined in 46 HCV-2 treatment-experienced patients (42 previous relapsers; four previous non-responders) retreated with 24-week peginterferon/ribavirin.

Results: Forty (87.0%) patients carried the rs8099917 TT genotype and 6 patients (13.0%) carried the TG/GG genotype. The sustained virological response (SVR; seronegativity of HCV RNA throughout 24 weeks of the post-treatment follow-up period) rate was 71.7%. Compared with previous non-responders, previous relapsers had a significantly higher SVR rate (78.6% vs. 0%, P = 0.004) and a lower relapse rate (17.5% vs. 100%, P = 0.04). All the previous non-responders were with the rs8099917 TT genotype. As for those who relapsed, treatment responses, including the rates of rapid virological response (RVR, 80.6% vs. 66.7%, P = 0.59), early virological response (EVR, 97.2% vs. 83.3%, P = 0.27), end-of-treatment virological response (97.2% vs. 83.3%, P = 0.27) and SVR (80.6% vs. 66.7%, P = 0.59) and relapse rate (17.1% vs. 20.0%, P = 1) did not differ significantly between patients with the rs8099917 TT and those with the non-TT genotype. Multivariate analysis revealed that the most important factor predictive of an SVR in the retreatment of HCV-2 was previous relapse; the only factor predictive of an SVR for previous relapsers was the achievement of an EVR. Compared with the achievement of a RVR, the attainment of an EVR was more accurate in predicting an SVR (88% vs. 74%).

Conclusions: Peginterferon/ribavirin is effective in the retreatment of HCV-2 relapsers, especially among those who achieved an EVR.

Conflict of interest statement

Competing Interests: The authors have read the journal's policy and have the following conflicts: co-author Ming-Lung Yu is the member of advisory board of Merck Sharp & Dohme (MSD), Roche and Abbott and on the PLOS editorial board. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Treatment responses between patients with different rs8099917 genotypes.
Black bar represents patients with rs8099917 TT genotype. Brown bar represents patients with rs8099917 GT/GG genotype. RVR, rapid virological response. EVR, early virological response. EOTVR, end of treatment virological response. SVR, sustained virological response.

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Grant support

This study was supported by a grant from the Kaohsiung Medical University Hospital (KMUH100-9I02) and a grant from the National Science Council, Taiwan (NSC 100-2314-B-037 -014 -MY2). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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