Sectoral loss of myelin and axons in anterior ischemic optic neuropathy

Optom Vis Sci. 2013 May;90(5):e138-41. doi: 10.1097/OPX.0b013e31828def45.

Abstract

Purpose: We report a case of focal myelinated nerve fiber (MNF) loss caused by anterior ischemic optic neuropathy.

Case report: A 62-year-old woman with segmental MNF presented with anterior ischemic optic neuropathy. One year later, MNF lost superiorly, with preservation of inferior segment MNF. Spectral-domain optical coherence tomography of the optic nerve head and posterior pole retinal thickness showed localized thinning of superior nerve fibers (axons) and retinal thickness.

Conclusions: This case highlights the focal nature of anterior ischemic optic neuropathy and may be the first patient in whom sectoral loss of myelinated nerve fiber has been photographically documented.

Publication types

  • Case Reports

MeSH terms

  • Axons / pathology
  • Disease Progression
  • Female
  • Humans
  • Middle Aged
  • Myelin Sheath / metabolism*
  • Nerve Fibers, Myelinated / metabolism
  • Nerve Fibers, Myelinated / pathology*
  • Optic Disk / metabolism
  • Optic Disk / pathology*
  • Optic Neuropathy, Ischemic / metabolism
  • Optic Neuropathy, Ischemic / pathology*
  • Retinal Ganglion Cells / metabolism
  • Retinal Ganglion Cells / pathology*
  • Tomography, Optical Coherence / methods