Two new bromophenols with radical scavenging activity from marine red alga Symphyocladia latiuscula

Xiuli Xu; Liyuan Yin; Lijie Gao; Junhai Gao; Junhui Chen; Jingxi Li; Fuhang Song

doi:10.3390/md11030842

Two new bromophenols with radical scavenging activity from marine red alga Symphyocladia latiuscula

Mar Drugs. 2013 Mar 13;11(3):842-7. doi: 10.3390/md11030842.

Authors

Xiuli Xu¹, Liyuan Yin, Lijie Gao, Junhai Gao, Junhui Chen, Jingxi Li, Fuhang Song

Affiliation

¹ School of Ocean Sciences, China University of Geosciences, Beijing 100083, China. xuxl@cugb.edu.cn

Abstract

Chemical investigation of a Chinese collection of marine red alga Symphyocladia latiuscula yielded two new highly brominated phenols. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including HRMS, 1D and 2D NMR and MS methods. Compounds 1 and 2 were evaluated for radical scavenging capability by 1,1-diphenyl-2-picrylhydrazuyl (DPPH) radical with the IC50 value of 14.5 and 20.5 μg/mL, respectively.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Biphenyl Compounds / chemistry
Bromine / chemistry
China
Free Radical Scavengers / chemistry
Free Radical Scavengers / isolation & purification
Free Radical Scavengers / pharmacology*
Inhibitory Concentration 50
Phenols / chemistry
Phenols / isolation & purification
Phenols / pharmacology*
Picrates / chemistry
Rhodophyta / chemistry*
Spectrum Analysis

Substances

Biphenyl Compounds
Free Radical Scavengers
Phenols
Picrates
1,1-diphenyl-2-picrylhydrazyl
Bromine