Microwave assisted Suzuki-Miyaura and Ullmann type homocoupling reactions of 2- and 3-halopyridines using a Pd(OAc)2/benzimidazolium salt and base catalyst system

Molecules. 2013 Mar 25;18(4):3712-24. doi: 10.3390/molecules18043712.

Abstract

A number of novel benzimidazole derivatives 1-4 were synthesized and the catalytic activity of these compounds in a catalytic system consisting of a benzimidazolium salt/Pd(OAc)2/K2CO3 were investigated in the Suzuki-Miyaura and Ullmann type homocoupling reactions under microwave irradiation. We obtained both cross coupling and homocoupling products of pyridine and some side products such as dimethylaminopyridine and unsubstituted pyridine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / analysis*
  • Acetates / chemistry*
  • Benzimidazoles / chemistry
  • Boronic Acids / chemistry
  • Catalysis
  • Gas Chromatography-Mass Spectrometry
  • Microwaves*
  • Molecular Structure
  • Organometallic Compounds / analysis*
  • Organometallic Compounds / chemistry*
  • Organoplatinum Compounds / chemistry
  • Pyridines / chemistry

Substances

  • Acetates
  • Benzimidazoles
  • Boronic Acids
  • Organometallic Compounds
  • Organoplatinum Compounds
  • Pyridines
  • palladium(II) acetate