Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jun;87(12):4879-83.
doi: 10.1073/pnas.87.12.4879.

Ubiquinol-10 Is an Effective Lipid-Soluble Antioxidant at Physiological Concentrations

Affiliations
Free PMC article

Ubiquinol-10 Is an Effective Lipid-Soluble Antioxidant at Physiological Concentrations

B Frei et al. Proc Natl Acad Sci U S A. .
Free PMC article

Abstract

It is well known that ubiquinone-10 (coenzyme Q10, ubiquinone 50) acts as an electron carrier of the respiratory chain in mitochondria. In this paper we show that ubiquinol-10, the reduced form of ubiquinone-10, also efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as alpha-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under our experimental conditions. In contrast to alpha-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. We also show that ubiquinol-10 spares alpha-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol-10, like alpha-tocopherol, does not interact with reduced glutathione. Our data together with previous work on the antioxidant function of ubiquinol reported in the literature strongly suggest that ubiquinol-10 is an important physiological lipid-soluble antioxidant.

Similar articles

See all similar articles

Cited by 71 articles

See all "Cited by" articles

References

    1. J Biol Chem. 1966 Oct 10;241(19):4353-6 - PubMed
    1. Arch Biochem Biophys. 1977 Apr 30;180(2):248-57 - PubMed
    1. Biochem J. 1979 Apr 15;180(1):129-35 - PubMed
    1. Am Heart J. 1980 Dec;100(6 Pt 1):829-37 - PubMed
    1. Ann Thorac Surg. 1982 Feb;33(2):145-51 - PubMed

Publication types

LinkOut - more resources

Feedback