Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice

Int Immunopharmacol. 2013 Apr;15(4):666-70. doi: 10.1016/j.intimp.2013.03.015. Epub 2013 Mar 25.


Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.

MeSH terms

  • Anaphylaxis / chemically induced
  • Anaphylaxis / immunology
  • Anaphylaxis / prevention & control*
  • Animals
  • Anti-Allergic Agents / isolation & purification
  • Anti-Allergic Agents / therapeutic use*
  • Basidiomycota / chemistry*
  • Cells, Cultured
  • Female
  • Immunoglobulin E / blood*
  • Immunoglobulin E / immunology
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / immunology
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / immunology
  • Spleen / cytology
  • Spleen / drug effects
  • Spleen / immunology
  • Th1 Cells / drug effects
  • Th1 Cells / immunology
  • p-Methoxy-N-methylphenethylamine / immunology
  • p-Methoxy-N-methylphenethylamine / toxicity*


  • Anti-Allergic Agents
  • Immunoglobulin E
  • p-Methoxy-N-methylphenethylamine
  • Interferon-gamma
  • Ovalbumin