Public health implications from COGS and potential for risk stratification and screening

Nat Genet. 2013 Apr;45(4):349-51. doi: 10.1038/ng.2582.


The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk assessment tools, new protocols for consent and programs of professional education and public engagement.

Publication types

  • Introductory Journal Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / genetics
  • Cooperative Behavior
  • Early Detection of Cancer*
  • Female
  • Humans
  • Male
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / genetics
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / genetics
  • Public Health*
  • Risk Assessment