Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration

Food Chem Toxicol. 2013 Nov;61:101-5. doi: 10.1016/j.fct.2013.03.018. Epub 2013 Mar 26.

Abstract

The present study focuses on the short term effects of repeated low level administration of turinabol and methanabol on cardiac function in young rabbits (4 months-old). The experimental scheme consisted of two oral administration periods, lasting 1 month each, interrupted by 1-month wash-out period. Serial echocardiographic evaluation at the end of all three experimental periods was performed in all animals. Oxidative stress markers have also been monitored at the end of each administration period. Treated animals originally showed significantly increased myocardial mass and systolic cardiac output, which normalized at the end of the wash out period. Re-administration led to increased cardiac output, at the cost though of a progressive myocardial mass reduction. A dose-dependent trend towards impaired longitudinal systolic, diastolic and global myocardial function was also observed. The adverse effects were more pronounced in the methanabol group. For both anabolic steroids studied, the low dose had no significant effects on oxidative stress markers monitored, while the high dose created a hostile oxidative environment. In conclusion, anabolic administration has been found to create a possible deleterious long term effect on the growth of the immature heart and should be strongly discouraged especially in young human subjects.

Keywords: Cardiotoxicity; Methanabol; Oxidative stress; Rabbits; Turinabol.

MeSH terms

  • Anabolic Agents / administration & dosage
  • Anabolic Agents / adverse effects
  • Anabolic Agents / pharmacology*
  • Animals
  • Catalase / metabolism
  • Dose-Response Relationship, Drug
  • Echocardiography
  • Female
  • Glutathione / metabolism
  • Heart / drug effects
  • Heart / physiopathology*
  • Methandrostenolone / administration & dosage
  • Methandrostenolone / adverse effects
  • Methandrostenolone / pharmacology*
  • Oxidative Stress / drug effects*
  • Rabbits
  • Testosterone / administration & dosage
  • Testosterone / adverse effects
  • Testosterone / analogs & derivatives*
  • Testosterone / pharmacology
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Anabolic Agents
  • Thiobarbituric Acid Reactive Substances
  • Testosterone
  • turinabol
  • Methandrostenolone
  • Catalase
  • Glutathione