Folate, vitamin B₁₂, and S-adenosylmethionine

Psychiatr Clin North Am. 2013 Mar;36(1):1-13. doi: 10.1016/j.psc.2012.12.001.


Folate (vitamin B9) and cobalamin (vitamin B12) are essential for the normal development and function of the central nervous system. The metabolism of these vitamins is intimately linked and supports the synthesis of S-adenosylmethionine (SAMe), the major methyl group donor in methylation reactions. This article reviews the metabolic and clinical importance of folate, vitamin B12, and SAMe, as well as clinical trials in relation to depression and dementia.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Dementia / drug therapy*
  • Depression / drug therapy*
  • Folic Acid / therapeutic use*
  • Humans
  • S-Adenosylmethionine / therapeutic use*
  • Vitamin B 12 / therapeutic use*


  • S-Adenosylmethionine
  • Folic Acid
  • Vitamin B 12