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Review
. 2013 Mar;36(1):1-13.
doi: 10.1016/j.psc.2012.12.001.

Folate, Vitamin B₁₂, and S-adenosylmethionine

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Review

Folate, Vitamin B₁₂, and S-adenosylmethionine

Teodoro Bottiglieri. Psychiatr Clin North Am. .

Abstract

Folate (vitamin B9) and cobalamin (vitamin B12) are essential for the normal development and function of the central nervous system. The metabolism of these vitamins is intimately linked and supports the synthesis of S-adenosylmethionine (SAMe), the major methyl group donor in methylation reactions. This article reviews the metabolic and clinical importance of folate, vitamin B12, and SAMe, as well as clinical trials in relation to depression and dementia.

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