Vildagliptin more effectively achieves a composite endpoint of HbA₁c < 7.0% without hypoglycaemia and weight gain compared with glimepiride after 2 years of treatment

Diabetes Res Clin Pract. 2013 Jun;100(3):e78-81. doi: 10.1016/j.diabres.2013.03.011. Epub 2013 Mar 26.

Abstract

This post hoc analysis reports that overall proportion of patients achieving a composite endpoint of HbA1c<7.0% (<53.0 mmol/mol) without hypoglycaemia and weight gain was higher with vildagliptin than glimepiride after 2 years in type 2 diabetes patients inadequately controlled on metformin monotherapy, regardless of age and duration of diabetes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / therapeutic use
  • Aged
  • Female
  • Glycated Hemoglobin / metabolism*
  • Humans
  • Hypoglycemia / drug therapy*
  • Hypoglycemic Agents / therapeutic use*
  • Male
  • Metformin / therapeutic use
  • Middle Aged
  • Nitriles / therapeutic use*
  • Pyrrolidines / therapeutic use*
  • Sulfonylurea Compounds / therapeutic use*
  • Vildagliptin
  • Weight Gain / drug effects

Substances

  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Nitriles
  • Pyrrolidines
  • Sulfonylurea Compounds
  • glimepiride
  • Metformin
  • Vildagliptin
  • Adamantane