Role of the ubiquitin proteasome system in the heart

Circ Res. 2013 Mar 29;112(7):1046-58. doi: 10.1161/CIRCRESAHA.112.300521.


Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease. The potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heart Failure / metabolism*
  • Heart Failure / physiopathology
  • Heart Failure / therapy
  • Humans
  • Myocardial Ischemia / metabolism*
  • Myocardial Ischemia / physiopathology
  • Myocardial Ischemia / therapy
  • Myocardium / enzymology*
  • Proteasome Endopeptidase Complex / metabolism*
  • Ubiquitin / metabolism*
  • Ventricular Remodeling / physiology*


  • Ubiquitin
  • Proteasome Endopeptidase Complex