Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 29;112(7):1046-58.
doi: 10.1161/CIRCRESAHA.112.300521.

Role of the Ubiquitin Proteasome System in the Heart


Role of the Ubiquitin Proteasome System in the Heart

Julia Pagan et al. Circ Res. .


Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease. The potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed.

Similar articles

See all similar articles

Cited by 32 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources