Vitamin D status and outcomes after renal transplantation

J Am Soc Nephrol. 2013 Apr;24(5):831-41. doi: 10.1681/ASN.2012060614. Epub 2013 Mar 28.

Abstract

Kidney transplant recipients usually have low vitamin D levels, especially in the early posttransplantation period, but the association between vitamin D status with renal outcomes is not well described in this population. Here, we studied a prospective cohort of 634 kidney recipients who underwent transplantation at a single institution between January 2005 and June 2010. In this cohort, low 25-hydroxyvitamin D concentrations 3 months after transplantation did not predict early death or graft loss but were independently associated with lower measured GFR at 12 months (P=0.001) and higher risk for interstitial fibrosis and tubular atrophy (P=0.01). In contrast, levels of calcium, phosphorus, calcitriol, parathyroid hormone, or fibroblast growth factor-23 were not consistently associated with any of the studied outcomes. In conclusion, low 25-hydroxyvitamin D concentration measured 3 months after transplantation is an independent risk factor for interstitial fibrosis progression and is associated with a lower GFR 1 year after transplantation.

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Female
  • Fibrosis
  • Glomerular Filtration Rate
  • Humans
  • Kidney / pathology
  • Kidney Transplantation* / mortality
  • Kidney Tubules / pathology
  • Male
  • Middle Aged
  • Prospective Studies
  • Transplantation, Homologous
  • Treatment Outcome
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • Vitamin D
  • 1,25-dihydroxyvitamin D
  • 25-hydroxyvitamin D