Lessons From the Cancer Genome

Cell. 2013 Mar 28;153(1):17-37. doi: 10.1016/j.cell.2013.03.002.

Abstract

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Genes, Neoplasm
  • Genome, Human
  • Genomics / methods*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neoplasms / therapy