A culture-specific nutrient intake assessment instrument in patients with pulmonary tuberculosis

Clin Nutr. 2013 Dec;32(6):1023-8. doi: 10.1016/j.clnu.2013.02.013. Epub 2013 Mar 5.


Background & aim: To develop and evaluate a culture-specific nutrient intake assessment tool for use in adults with pulmonary tuberculosis (TB) in Tbilisi, Georgia.

Methods: We developed an instrument to measure food intake over 3 consecutive days using a questionnaire format. The tool was then compared to 24 h food recalls. Food intake data from 31 subjects with TB were analyzed using the Nutrient Database System for Research (NDS-R) dietary analysis program. Paired t-tests, Pearson correlations and intraclass correlation coefficients (ICC) were used to assess the agreement between the two methods of dietary intake for calculated nutrient intakes.

Results: The Pearson correlation coefficient for mean daily caloric intake between the 2 methods was 0.37 (P = 0.04) with a mean difference of 171 kcals/day (p = 0.34). The ICC was 0.38 (95% CI: 0.03-0.64) suggesting the within-patient variability may be larger than between-patient variability. Results for mean daily intake of total fat, total carbohydrate, total protein, retinol, vitamins D and E, thiamine, calcium, sodium, iron, selenium, copper, and zinc between the two assessment methods were also similar.

Conclusions: This novel nutrient intake assessment tool provided quantitative nutrient intake data from TB patients. These pilot data can inform larger studies in similar populations.

Keywords: ACTSI; Assessment; Atlanta Clinical and Translational Science Institute; CCC; CRF; Diet; FFQ; Georgian National Center for Tuberculosis and Lung Diseases; ICC; MDR; Macronutrient; Micronutrient; NCTBLD; NDS-R; Nutrient Database System for Research; Nutrition; RCT; TB; Tuberculosis; case report form; concordance correlation coefficient; food frequency questionnaire; intraclass correlation coefficient; multi-drug resistant tuberculosis; randomized clinical trial; tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Diet Records
  • Diet Surveys
  • Dietary Carbohydrates / administration & dosage
  • Dietary Fats / administration & dosage
  • Dietary Proteins / administration & dosage
  • Energy Intake / ethnology*
  • Female
  • Georgia (Republic)
  • Humans
  • Male
  • Nutrition Assessment*
  • Pilot Projects
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Trace Elements / administration & dosage
  • Tuberculosis, Pulmonary / diet therapy*
  • Vitamins / administration & dosage


  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins
  • Trace Elements
  • Vitamins