[Renal urinary shear stress: a novel actor in nephropathies]

Med Sci (Paris). 2013 Mar;29(3):279-85. doi: 10.1051/medsci/2013293014. Epub 2013 Mar 27.
[Article in French]

Abstract

The role of fluid shear stress is well established in vascular pathophysiology. However, urinary shear stress now also appears as a key mechanism in the regulation of renal function. In addition, there is a growing body of evidence showing that modified urinary shear stress is involved in the development of nephropathies. Therefore we review here the state-of-the-art on the pathophysiological roles of urinary shear stress.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cytoskeleton / ultrastructure
  • Humans
  • Kidney Diseases / etiology*
  • Kidney Diseases / physiopathology
  • Kidney Tubules / ultrastructure
  • Polycystic Kidney Diseases / physiopathology
  • Rheology*
  • Urine / physiology*