Chromatin architecture defines the glucocorticoid response

Mol Cell Endocrinol. 2013 Nov 5;380(1-2):25-31. doi: 10.1016/j.mce.2013.03.020. Epub 2013 Mar 29.


The glucocorticoid receptor (GR) functions to regulate a wide group of physiological processes through hormone inducible interaction with genomic loci and subsequent manipulation of the transcriptional output of target genes. Despite expression in a wide variety of tissues, the GR has diverse roles that are regulated tightly in a cell type specific manner. With the advent of whole genome approaches, the details of that diversity and the mechanisms regulating them are beginning to be elucidated. This review aims describe the recent advances detailing the role chromatin structure plays in dictating GR specificity.

Keywords: Chromatin; Glucocorticoid receptor; Nuclear receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Chromatin / genetics*
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly
  • Genome, Human
  • Glucocorticoids / physiology*
  • Humans
  • Nucleic Acid Conformation
  • Promoter Regions, Genetic
  • Protein Binding
  • Receptors, Glucocorticoid / physiology


  • Chromatin
  • Glucocorticoids
  • Receptors, Glucocorticoid