The Drosophila clotting system and its messages for mammals

Dev Comp Immunol. 2014 Jan;42(1):42-6. doi: 10.1016/j.dci.2013.03.014. Epub 2013 Mar 30.


Drosophila has been increasingly used as a model to study hemolymph clotting. Proteomics and bioinformatics identified candidate clotting-factors, several of which were tested using genetics. Mutants and lines with reduced expression of clotting-factors show subtle effects after wounding, indicating that sealing wounds may rely on redundant mechanisms. More striking effects are observed after infection, in particular when a natural infection model involving entomopathogenic nematodes is used. When translated into mammalian models these results reveal that mammalian blood clots serve a similar immune function, thus providing a new example of the usefulness of studying invertebrate models.

Keywords: APMAP; Hml; Ig; Innate immunity; Insect immunity; Phenoloxidase; Transglutaminase; adipocyte membrane associated protein; hemolectin; immunoglobulin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Coagulation / genetics
  • Blood Coagulation / immunology
  • Blood Coagulation Disorders / genetics
  • Blood Coagulation Disorders / immunology*
  • Blood Proteins / immunology*
  • Computational Biology / methods
  • Disease Models, Animal
  • Drosophila Proteins / genetics
  • Drosophila Proteins / immunology*
  • Drosophila melanogaster / immunology*
  • Hemolymph / immunology*
  • Humans
  • Mammals
  • Proteomics / methods


  • Blood Proteins
  • Drosophila Proteins