Disruption of the intestinal mucosal barrier in Candida albicans infections

Microbiol Res. 2013 Aug 25;168(7):389-95. doi: 10.1016/j.micres.2013.02.008. Epub 2013 Mar 30.

Abstract

Candida albicans is a common microorganism in the intestine. However, invasive C. albicans infection has emerged as a life-threatening disease in recent years. The mortality rate of invasive candidiasis is high in critically ill hosts. C. albicans can switch from the yeast to the hyphal morphology, and take advantage of the impaired intestinal mucosal barrier and insufficient immunity of the host to facilitate its colonization and penetration. Despite the availability of potent new antifungal drugs in recent years, the treatment of severe candidiasis, especially candidaemia, has not been substantially improved. In this review, the virulence factors of C. albicans, as well as the antagonistic role of the intestinal mucosal barrier will be discussed to illuminate the mechanisms of C. albicans enterogenic infections.

Publication types

  • Review

MeSH terms

  • Animals
  • Candida albicans / genetics
  • Candida albicans / growth & development
  • Candida albicans / pathogenicity
  • Candida albicans / physiology*
  • Candidiasis / immunology
  • Candidiasis / microbiology*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Humans
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / microbiology*
  • Virulence Factors / genetics
  • Virulence Factors / metabolism

Substances

  • Fungal Proteins
  • Virulence Factors